





The committee could not finalize the assessment of some other flavoring agents, requiring further information. JECFA highlighted the importance of receiving complete data submissions from the sponsors for conducting the safety evaluation.

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Most commonly used in candy, it can also be found in salad dressings, chewing gum, ice cream, frozen pizzas, drink and jello mixes and many other food categories. Titanium dioxide creates a smooth finish and adds shine and brightness to other colors.
Analyst Insight
The FDA has issued guidance clarifying the safe use of titanium dioxide pigment as a food colorant and has stated that titanium dioxide may be safely used in cosmetics, including those intended for use around the eye. FDA also regulates the safety and effectiveness of sunscreen active ingredients, including nanoscale titanium dioxide.
Titanium dioxide can amplify and brighten white opacity because of its exceptional light-scattering properties. In food and drugs, these properties help to define colors clearly and can prevent products from UV degradation.


No. EFSA’s role was limited to evaluating the risks linked to titanium dioxide as a food additive. This included an assessment of relevant scientific information on TiO2, its potential toxicity, and estimates of human dietary exposure. Any legislative or regulatory decisions on the authorisations of food additives are the responsibility of the risk managers (i.e. European Commission and Member States).
Fig. 5. ROS values (Abs of NBT) in samples of MSSA treated with A: 0.2 mg/mL P25TiO2NPs; B: 0.02 mg/mL P25TiO2NPs; C: 0.2 mg/mL VitaminB2@P25TiO2NPs; D: 0.02 mg/mL VitaminB2@P25TiO2NPs after 3 h of irradiation (red) and 6 h (blue). SD < 0.20 and p < 0.05 between C-D and A-B.
Nano, or ultrafine, TiO2 comprises primary particles sized less than 100nm. In this grade, titanium dioxide is transparent (colourless) and boasts improved UV scattering and absorbing properties compared with larger particle-size pigmentary TiO2.